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We discover and develop novel, "best-in-class" inhibitors of CYP17, a validated metalloenzyme involved in prostate cancer.

About Us

About Us

CYP17 lyase inhibitors have high commercial potential for the treatment of  breast cancer and CRPC as well as other cancers that utilize androgens as growth factors (e.g., ovarian, bladder, hepatocellular, and lung). Selective CYP17 lyase inhibitors also have potential for the treatment of non-oncologic syndromes that are due to excessive androgen production such as endometriosis, polycystic ovary syndrome, congenital adrenal hyperplasia, and precocious puberty.

Intellectual Property

Our lead molecule, seviteronel (formerly VT-464), and multiple classes of chemically-distinct CYP17 lyase inhibitors are covered by composition of matter and use patents through at least 2031. This intellectual property is wholly owned by Innocrin, with no financial obligations due to third parties.